Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL747240 | 0.80 | POLB (0.55) | POLBHCAR2HTTALOX15KDM4E | |
| SCHEMBL13808099 | 0.80 | POLB (0.55) | POLBHCAR2HTTALOX15KDM4E | |
| SCHEMBL15400735 | 0.80 | POLB (0.55) | POLBHCAR2HTTALOX15KDM4E | |
| Formaldehyde SCHEMBL27682220 | 0.78 | HCAR2 (0.92) | POLBHCAR2HTTALOX15KDM4E | |
| SCHEMBL29603529 | 0.77 | HCAR2 (1.00) | POLBHCAR2HTTALOX15KDM4E | |
| SCHEMBL112388 | 0.77 | HCAR2 (1.00) | POLBHCAR2HTTALOX15KDM4E | |
| SCHEMBL1502732 | 0.77 | POLB (0.52) | POLBHCAR2HTTALOX15KDM4E | |
| SCHEMBL10461109 | 0.76 | HCAR2 (0.96) | POLBHCAR2HTTALOX15KDM4E | |
| Hydrochloric Acid SCHEMBL30444355 | 0.76 | HCAR2 (0.96) | POLBHCAR2HTTALOX15KDM4E | |
| Hydrochloric Acid SCHEMBL6525205 | 0.76 | HCAR2 (0.96) | POLBHCAR2HTTALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3575288-A1 | QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-12-04 | — | — | EP | disclosed |
| EP-3124475-B1 | QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-08-07 | — | — | EP | disclosed |
| EP-3124475-A1 | QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-02-01 | — | — | EP | disclosed |