Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.75 |
| ▸ | TGFBR2 | P37173 | 10/20 | 0.75 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18045180 | 0.85 | TGFBR1 (1.00) | TGFBR1TGFBR2TGFB2 | |
| SCHEMBL18554245 | 0.77 | TGFBR1 (0.76) | TGFBR1TGFBR2TGFB2 | |
| SCHEMBL18456435 | 0.77 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18554228 | 0.77 | TGFBR1 (0.71) | TGFBR1TGFBR2 | |
| SCHEMBL18554301 | 0.72 | TGFBR1 (0.73) | TGFBR1TGFBR2TGFB2 | |
| SCHEMBL18456577 | 0.72 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18456437 | 0.72 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL18554130 | 0.72 | TGFBR1 (0.66) | TGFBR1TGFBR2 | |
| SCHEMBL18554210 | 0.71 | TGFBR1 (0.64) | TGFBR1TGFBR2 | |
| SCHEMBL20421657 | 0.71 | TGFBR1 (0.85) | TGFBR1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017019757-A1 | TGF BETA RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-02-02 | — | — | WO | disclosed |