Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 7/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28211105 | 0.84 | MAPT (0.44) | CHEK2HDAC1MAPTIKBKBALDH1A1 | |
| SCHEMBL29713875 | 0.81 | MAPT (0.41) | CHEK2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL27223707 | 0.81 | MAPT (0.41) | CHEK2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL31403418 | 0.80 | HSD17B1 (0.54) | PRKCIMAPTCREBBPNPC1RAB9A | |
| SCHEMBL3790376 | 0.77 | PRKCI (0.50) | PRKCIMAPTCREBBPNPC1RAB9A | |
| SCHEMBL3800105 | 0.77 | MAPT (0.55) | PRKCIMAPTALDH1A1CREBBPNPC1 | |
| SCHEMBL18458311 | 0.77 | MAPT (0.48) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL18458070 | 0.76 | IDH2 (0.53) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9537225 | 0.76 | MAPT (0.53) | PRKCIMAPTALDH1A1CREBBPNPC1 | |
| SCHEMBL6516791 | 0.74 | HSD17B1 (0.55) | CHEK2HDAC1MAPTCHEK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330263-B1 | PHENYLUREA DERIVATIVES AS ISOCITRATE DEHYDROGENASE 2 INHIBITORS FOR TREATING CANCER | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2020-11-18 | — | — | EP | disclosed |
| US-10155722-B2 | Antitumor compound targeting IDH2 mutation and method of use thereof | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-12-18 | — | — | US | disclosed |
| US-20180222853-A1 | ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| US-20180222853-A1 | ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| US-20180222853-A1 | ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| EP-3330263-A1 | ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF | Chia Tai Tianqing Pharmaceutical Group Co.,Ltd (CN) | 2018-06-06 | — | — | EP | disclosed |
| WO-2017016523-A1 | ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF | 正大天晴药业集团股份有限公司 | 2017-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10155722-B2 | Antitumor compound targeting IDH2 mutation and method of use thereof | IDH2, IDH3A, IDH1 | CHEK2 103/4885PRKCI 973/4885HDAC1 172/4885 |
| US-20180222853-A1 | ANTITUMOR COMPOUND TARGETING IDH2 MUTATION AND METHOD OF USE THEREOF | IDH2, IDH3A, IDH1 | CHEK2 103/4885PRKCI 973/4885HDAC1 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.