Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.64 |
| ▸ | IDH2 | P48735 | 16/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18459269 | 1.00 | IDH1 (0.64) | IDH1IDH2 | |
| SCHEMBL18459563 | 0.94 | IDH1 (0.62) | IDH1IDH2 | |
| SCHEMBL21518019 | 0.93 | IDH1 (0.61) | IDH1IDH2 | |
| SCHEMBL18459835 | 0.93 | IDH1 (0.61) | IDH1IDH2 | |
| SCHEMBL21517986 | 0.93 | IDH1 (0.62) | IDH1IDH2 | |
| SCHEMBL18459834 | 0.93 | IDH1 (0.62) | IDH1IDH2 | |
| SCHEMBL18459833 | 0.92 | IDH1 (0.76) | IDH1IDH2 | |
| SCHEMBL18459285 | 0.91 | IDH1 (0.76) | IDH1IDH2 | |
| SCHEMBL18459830 | 0.91 | IDH1 (0.76) | IDH1IDH2 | |
| SCHEMBL18459267 | 0.90 | IDH1 (0.55) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849059-B | 7-phenylethylamino-4H-pyrimido [4,5-D ] [1,3] oxazin-2-one compounds and their use as inhibitors of mutant IDH1 | 伊莱利利公司 | 2020-04-28 | — | — | CN | disclosed |
| EP-3328866-B1 | 7-PHENYLETHYLAMINO-4H-PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AND THEIT USE AS MUTANT IDH1 INHIBITORS | LILLY CO ELI (US) | 2019-10-30 | — | — | EP | disclosed |
| EP-3328866-B1 | 7-PHENYLETHYLAMINO-4H-PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AND THEIT USE AS MUTANT IDH1 INHIBITORS | LILLY CO ELI (US) | 2019-10-30 | — | — | EP | disclosed |
| WO-2017019429-A1 | 7-PHENYLETHYLAMINO-4H-PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AND THEIT USE AS MUTANT IDH1 INHIBITORS | ELI LILLY AND COMPANY (US) | 2017-02-02 | — | — | WO | disclosed |