Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.61 |
| ▸ | IDH2 | P48735 | 15/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18459835 | 1.00 | IDH1 (0.61) | IDH1IDH2 | |
| SCHEMBL18459563 | 0.95 | IDH1 (0.62) | IDH1IDH2 | |
| SCHEMBL18459593 | 0.93 | IDH1 (0.64) | IDH1IDH2 | |
| SCHEMBL18459269 | 0.93 | IDH1 (0.64) | IDH1IDH2 | |
| SCHEMBL18459834 | 0.92 | IDH1 (0.62) | IDH1IDH2 | |
| SCHEMBL21517986 | 0.92 | IDH1 (0.62) | IDH1IDH2 | |
| SCHEMBL18459833 | 0.89 | IDH1 (0.76) | IDH1IDH2 | |
| SCHEMBL18459285 | 0.89 | IDH1 (0.76) | IDH1IDH2 | |
| SCHEMBL18459830 | 0.89 | IDH1 (0.76) | IDH1IDH2 | |
| SCHEMBL21517971 | 0.87 | IDH1 (0.80) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328866-B1 | 7-PHENYLETHYLAMINO-4H-PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AND THEIT USE AS MUTANT IDH1 INHIBITORS | LILLY CO ELI (US) | 2019-10-30 | — | — | EP | disclosed |