Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 1/20 | 0.45 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18459838 | 1.00 | SLC5A1 (0.45) | SLC5A1SLC5A2ALOX5APFEN1CHEK2 | |
| SCHEMBL21618375 | 0.84 | GPR119 (0.48) | SLC5A1SLC5A2ALOX5APFEN1CHEK2 | |
| SCHEMBL15300717 | 0.83 | SLC5A1 (0.47) | SLC5A1SLC5A2CHEK2NAMPTGPR119 | |
| SCHEMBL796329 | 0.82 | NAMPT (0.54) | SLC5A1SLC5A2ALOX5APFEN1NAMPT | |
| SCHEMBL29126588 | 0.81 | GPR119 (0.47) | SLC5A1SLC5A2CHEK2NAMPTGPR119 | |
| SCHEMBL29304279 | 0.81 | GPR119 (0.53) | GPR119 | |
| SCHEMBL23693081 | 0.80 | GPR119 (0.48) | SLC5A1SLC5A2ALOX5APFEN1CHEK2 | |
| SCHEMBL10223291 | 0.79 | NPC1 (0.61) | CHEK2GPR119NPC1ALDH1A1MAPT | |
| SCHEMBL29126576 | 0.78 | GPR119 (0.47) | SLC5A1SLC5A2CHEK2NAMPTGPR119 | |
| SCHEMBL17554504 | 0.77 | SLC5A1 (0.46) | SLC5A1SLC5A2ALOX5APFEN1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849059-B | 7-phenylethylamino-4H-pyrimido [4,5-D ] [1,3] oxazin-2-one compounds and their use as inhibitors of mutant IDH1 | 伊莱利利公司 | 2020-04-28 | — | — | CN | disclosed |
| EP-3328866-B1 | 7-PHENYLETHYLAMINO-4H-PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AND THEIT USE AS MUTANT IDH1 INHIBITORS | LILLY CO ELI (US) | 2019-10-30 | — | — | EP | disclosed |
| WO-2017019429-A1 | 7-PHENYLETHYLAMINO-4H-PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AND THEIT USE AS MUTANT IDH1 INHIBITORS | ELI LILLY AND COMPANY (US) | 2017-02-02 | — | — | WO | disclosed |