Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.39 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12403886 | 0.72 | MAPT (0.49) | ALDH1A1MAPTKDM4EHIF1AHSD17B10 | |
| SCHEMBL3439599 | 0.69 | MAPT (0.57) | ALDH1A1MAPTKDM4EHIF1AHSD17B10 | |
| SCHEMBL15305883 | 0.69 | MEN1 (0.46) | ALDH1A1MAPTKDM4EHIF1AHSD17B10 | |
| SCHEMBL21895251 | 0.67 | KDM4E (0.48) | ALDH1A1MAPTKDM4EHIF1AHSD17B10 | |
| SCHEMBL11156546 | 0.67 | ALDH1A1 (0.34) | ALDH1A1MAPTKDM4EKMT2ALMNA | |
| SCHEMBL762283 | 0.66 | MAPT (0.57) | ALDH1A1MAPTKDM4EHIF1AHSD17B10 | |
| SCHEMBL14661398 | 0.66 | KDM4E (0.57) | ALDH1A1MAPTKDM4EHIF1AHSD17B10 | |
| SCHEMBL13866406 | 0.66 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EHIF1AHSD17B10 | |
| SCHEMBL12775851 | 0.66 | KDM4E (0.47) | ALDH1A1MAPTKDM4EHIF1AHSD17B10 | |
| SCHEMBL198065 | 0.65 | MAPT (0.61) | ALDH1A1MAPTKDM4EHIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10307428-B2 | Therapeutic compositions for diabetic symmetrical polyneuropathy | UNIVERSITY HEALTH NETWORK (CA) | 2019-06-04 | — | — | US | disclosed |
| US-20190046540-A1 | TREATMENTS FOR DIABETIC SYMMETRICAL POLYNEUROPATHY | UNIVERSITY HEALTH NETWORK (CA) | 2019-02-14 | — | — | US | disclosed |
| US-20170027957-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF PERIPHERAL NEUROPATHIES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170027957-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF PERIPHERAL NEUROPATHIES | PMP22, CHRNA7, CHRNB3 | ALDH1A1 4187/4885MAPT 1835/4885KDM4E 4076/4885 |
| US-20190046540-A1 | TREATMENTS FOR DIABETIC SYMMETRICAL POLYNEUROPATHY | CHRNA5, CHRM2, CHRNE | ALDH1A1 4092/4885MAPT 592/4885KDM4E 3603/4885 |
| US-10307428-B2 | Therapeutic compositions for diabetic symmetrical polyneuropathy | CHRNA5, CHRM2, GAP43 | ALDH1A1 4253/4885MAPT 397/4885KDM4E 3675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.