Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 17/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.67 |
| ▸ | KDR | P35968 | 1/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.63 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1843679 | 0.91 | RAF1 (0.70) | RAF1RIPK2KDRMAPK13MAPK14 | |
| SCHEMBL1843970 | 0.85 | RAF1 (0.68) | RAF1RIPK2KDRMAPK13MAPK14 | |
| SCHEMBL939254 | 0.84 | RAF1 (0.80) | RAF1RIPK2KDRMAPK13MAPK14 | |
| SCHEMBL938059 | 0.83 | RAF1 (0.78) | RAF1RIPK2KDRMAPK13MAPK14 | |
| SCHEMBL668459 | 0.81 | RAF1 (1.00) | RAF1RIPK2KDRMAPK13MAPK14 | |
| SCHEMBL13946067 | 0.80 | RAF1 (0.82) | RAF1RIPK2KDRMAPK13MAPK14 | |
| SCHEMBL13234850 | 0.79 | RAF1 (1.00) | RAF1RIPK2KDRMAPK13MAPK14 | |
| SCHEMBL667817 | 0.79 | RAF1 (0.80) | RAF1RIPK2KDRMAPK13MAPK14 | |
| SCHEMBL938807 | 0.79 | FLT3 (0.58) | RAF1RIPK2KDRMAPK13MAPK14 | |
| SCHEMBL938074 | 0.79 | MAPT (0.57) | RAF1RIPK2KDRMAPK13MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324825-A1 | Aryl ureas with angiogenesis inhibiting activity | Bayer Healthcare LLC (US) | 2011-05-25 | — | — | EP | claimed |
| EP-2324825-A1 | Aryl ureas with angiogenesis inhibiting activity | Bayer Healthcare LLC (US) | 2011-05-25 | — | — | EP | disclosed |