Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27365079 | 0.84 | ALDH1A1 (0.55) | ALDH1A1TP53SMN1; SMN2GAAMAPT | |
| SCHEMBL14639021 | 0.84 | ALDH1A1 (0.55) | ALDH1A1TP53SMN1; SMN2GAAMAPT | |
| Hydrochloric Acid SCHEMBL1371669 | 0.82 | ALDH1A1 (0.54) | ALDH1A1TP53SMN1; SMN2GAAMAPT | |
| SCHEMBL31075110 | 0.81 | HRH3 (0.48) | ALDH1A1SMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL10516690 | 0.79 | SMN1; SMN2 (0.60) | ALDH1A1TP53SMN1; SMN2GAAMAPT | |
| SCHEMBL14067030 | 0.79 | TP53 (0.55) | ALDH1A1TP53SMN1; SMN2GAAMAPT | |
| SCHEMBL12437051 | 0.79 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2GAAMAPTMEN1 | |
| SCHEMBL19488417 | 0.79 | SMN1; SMN2 (0.53) | ALDH1A1TP53SMN1; SMN2GAAMAPT | |
| SCHEMBL24577905 | 0.78 | KDM4E (0.47) | ALDH1A1SMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL9912438 | 0.77 | KDM4E (0.50) | SMN1; SMN2GAAKDM4EPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9562003-B2 | Methods of using substituted tetracycline compounds to modulate RNA | PARATEK PHARMACEUTICALS, INC. (US) | 2017-02-07 | — | — | US | disclosed |
| US-9562003-B2 | Methods of using substituted tetracycline compounds to modulate RNA | PARATEK PHARMACEUTICALS, INC. (US) | 2017-02-07 | — | — | US | disclosed |