SCHEMBL184693

SCHEMBL184693

O=C(Nc1nc(C(O)CO)ns1)C(Oc1ccc(F)cc1F)c1ccc(S(=O)(=O)N2CCCCC2)cc1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 17/20 0.64
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL185262 0.86 GCK (0.64) GCKKMT2A
SCHEMBL185150 0.80 GCK (0.71) GCKKMT2A
SCHEMBL184635 0.80 GCK (0.75) GCKKMT2A
SCHEMBL184841 0.79 GCK (0.75) GCKKMT2A
SCHEMBL185060 0.79 GCK (0.73) GCKKMT2A
SCHEMBL19921745 0.79 GCK (0.63) GCK
SCHEMBL184721 0.78 GCK (1.00) GCKKMT2A
SCHEMBL3779285 0.78 GCK (0.70) GCKKMT2A
SCHEMBL184257 0.78 GCK (0.73) GCKKMT2A
SCHEMBL185123 0.78 GCK (0.73) GCKKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2402327-A1 Acetamide compounds as glucokinase activators, their process and medicinal applications Advinus Therapeutics Private Limited (IN) 2012-01-04 EP claimed
EP-2402327-B1 Acetamide compounds as glucokinase activators, their process and medicinal applications IMPETIS BIOSCIENCES LTD (IN) 2018-03-07 EP disclosed
EP-2402327-A1 Acetamide compounds as glucokinase activators, their process and medicinal applications Advinus Therapeutics Private Limited (IN) 2012-01-04 EP disclosed