Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 16/20 | 0.54 |
| ▸ | CDK2 | P24941 | 9/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.54 |
| ▸ | CDK7 | P50613 | 4/20 | 0.54 |
| ▸ | ABL1 | P00519 | 3/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.54 |
| ▸ | RET | P07949 | 3/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.54 |
| ▸ | BCR | P11274 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | FES | P07332 | 2/20 | 0.54 |
| ▸ | LYN | P07948 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 2/20 | 0.54 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.54 |
| ▸ | FER | P16591 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18485250 | 0.97 | AURKA (0.51) | AURKACDK2AURKBCDK7ABL1 | |
| SCHEMBL18471602 | 0.94 | AURKA (0.59) | AURKACDK2AURKBCDK7ABL1 | |
| SCHEMBL21372407 | 0.82 | AURKA (0.68) | AURKACDK2AURKBCDK7ABL1 | |
| SCHEMBL21372312 | 0.82 | AURKA (0.68) | AURKACDK2AURKBCDK7ABL1 | |
| SCHEMBL21372408 | 0.79 | AURKA (0.67) | AURKACDK2AURKBCDK7ABL1 | |
| SCHEMBL21372311 | 0.79 | AURKA (0.67) | AURKACDK2AURKBCDK7ABL1 | |
| SCHEMBL18484432 | 0.74 | AURKA (0.83) | AURKACDK2AURKBCDK7ABL1 | |
| SCHEMBL29188480 | 0.74 | AURKA (0.79) | AURKACDK2AURKBCDK7ABL1 | |
| SCHEMBL29188478 | 0.74 | AURKA (0.79) | AURKACDK2AURKBCDK7ABL1 | |
| SCHEMBL25649544 | 0.73 | AURKA (0.77) | AURKACDK2AURKBCDK7ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969753-B2 | BCR-ABL diploid inhibitor, synthesizing method therefor, and uses thereof | SHENZHEN YONGZE PHARMACEUTICAL CO., LTD. (CN) | 2018-05-15 | — | — | US | disclosed |
| US-20170037061-A1 | BCR-ABL Diploid Inhibitor, Synthesizing Method Therefor, and Uses Thereof | SHENZHEN YONGZE PHARMACEUTICAL CO., LTD. (CN) | 2017-02-09 | — | — | US | disclosed |
| US-20170037061-A1 | BCR-ABL Diploid Inhibitor, Synthesizing Method Therefor, and Uses Thereof | SHENZHEN YONGZE PHARMACEUTICAL CO., LTD. (CN) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037061-A1 | BCR-ABL Diploid Inhibitor, Synthesizing Method Therefor, and Uses Thereof | BCR, ABL1, BOD1L1 | AURKA 496/4885CDK2 112/4885AURKB 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.