Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 9/20 | 0.64 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852376 | 0.82 | CMA1 (0.60) | CMA1LMNATSHR | |
| SCHEMBL18887417 | 0.81 | CMA1 (0.60) | CMA1GPR84GRM2GRM3 | |
| SCHEMBL7951727 | 0.78 | CMA1 (1.00) | CMA1GPR84TSHR | |
| SCHEMBL7959067 | 0.77 | CMA1 (0.85) | CMA1GPR84TSHR | |
| SCHEMBL3418056 | 0.74 | CMA1 (1.00) | CMA1GPR84POLB | |
| SCHEMBL18900854 | 0.74 | CMA1 (0.76) | CMA1GPR84TSHR | |
| SCHEMBL7963672 | 0.73 | CMA1 (0.67) | CMA1GPR84TSHR | |
| SCHEMBL7960524 | 0.72 | CMA1 (1.00) | CMA1GPR84POLB | |
| SCHEMBL7966175 | 0.71 | CMA1 (0.81) | CMA1GPR84LMNAPOLB | |
| SCHEMBL7959611 | 0.71 | CMA1 (0.77) | CMA1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323991-A2 | CHYMASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | disclosed |