SCHEMBL1848015

SCHEMBL1848015

CCC(I)(N=C=O)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 1/20 0.34
MAPT P10636 3/20 0.33
KMT2A Q03164 2/20 0.33
GABRA1 P14867 1/20 0.32
GABRB2 P47870 1/20 0.32
CYP2C19 P33261 1/20 0.32
HIF1A Q16665 1/20 0.32
ALDH1A1 P00352 3/20 0.32
LMNA P02545 2/20 0.32
HPGD P15428 1/20 0.32
MAPK1 P28482 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
TAAR1 Q96RJ0 1/20 0.31
KIF11 P52732 1/20 0.31
TSHR P16473 2/20 0.31
RIPK1 Q13546 2/20 0.30
NR3C2 P08235 1/20 0.30
DRD2 P14416 1/20 0.30
OPRM1 P35372 1/20 0.30
DRD3 P35462 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17942152 0.77 KCNN4 (0.36) KCNN4MAPTKMT2AGABRA1GABRB2
SCHEMBL11040590 0.77 KCNN4 (0.36) KCNN4MAPTKMT2AGABRA1GABRB2
SCHEMBL5246503 0.75 KMT2A (0.41) KCNN4MAPTKMT2ACYP2C19HIF1A
SCHEMBL540818 0.75 KMT2A (0.41) KCNN4MAPTKMT2ACYP2C19HIF1A
SCHEMBL1556686 0.75 KMT2A (0.41) KCNN4MAPTKMT2ACYP2C19HIF1A
SCHEMBL28366939 0.73 KCNN4 (0.33) KCNN4GABRA1GABRB2CYP2C19HIF1A
SCHEMBL27675034 0.71 RIPK1 (0.38) KCNN4MAPTKMT2ACYP2C19HIF1A
SCHEMBL28027917 0.70 CYP2C19 (0.36) MAPTKMT2ACYP2C19HIF1AALDH1A1
SCHEMBL5892151 0.70 KCNN4 (0.34) KCNN4KMT2AGABRA1GABRB2CYP2C19
SCHEMBL109897 0.70 MAPK1 (0.39) KCNN4MAPTKMT2ACYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2323994-A1 SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 Boehringer Ingelheim International GmbH (DE) 2011-05-25 EP disclosed
EP-2183229-A1 SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 Vitae Pharmaceuticals, Inc. (US) 2010-05-12 EP disclosed
EP-2183228-A1 CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 Vitae Pharmaceuticals, Inc. (US) 2010-05-12 EP disclosed
WO-2010010150-A1 SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-01-28 WO disclosed
WO-2009017664-A1 CYCLIC INHIBITORS OF 11β-HYDROXYSTERIOD DEHYDROGENASE 1 VITAE PHARMACEUTICALS, INC. (US) 2009-02-05 WO disclosed
WO-2009017671-A1 SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 VITAE PHARMACEUTICALS, INC. (US) 2009-02-05 WO disclosed