SCHEMBL1848064

SCHEMBL1848064

N#Cc1sc(NC(=O)C2CCCC2)nc1-c1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 12/20 0.63
ADORA1 P30542 12/20 0.63
ADORA3 P0DMS8 4/20 0.53
ALDH1A1 P00352 3/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
NPC1 O15118 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
RAB9A P51151 1/20 0.52
KDM4E B2RXH2 2/20 0.51
MAPT P10636 2/20 0.51
LMNA P02545 1/20 0.51
HPGD P15428 1/20 0.51
HTT P42858 1/20 0.51
GSK3A P49840 1/20 0.49
GSK3B P49841 1/20 0.49
CASR P41180 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1847935 0.99 ADORA2A (0.62) ADORA2AADORA1ADORA3ALDH1A1SMN1; SMN2
SCHEMBL1852973 0.93 ADORA2A (0.59) ADORA2AADORA1ADORA3ALDH1A1SMN1; SMN2
SCHEMBL1852776 0.93 ADORA2A (0.59) ADORA2AADORA1ADORA3ALDH1A1SMN1; SMN2
SCHEMBL1852886 0.93 ADORA2A (0.59) ADORA2AADORA1ADORA3ALDH1A1SMN1; SMN2
SCHEMBL1850864 0.90 ADORA2A (0.53) ADORA2AADORA1ADORA3ALDH1A1SMN1; SMN2
SCHEMBL1848341 0.90 ADORA2A (0.53) ADORA2AADORA1ADORA3ALDH1A1SMN1; SMN2
SCHEMBL1852017 0.90 ADORA2A (0.53) ADORA2AADORA1ADORA3ALDH1A1SMN1; SMN2
SCHEMBL1852019 0.90 ADORA2A (0.53) ADORA2AADORA1ADORA3ALDH1A1SMN1; SMN2
SCHEMBL1848345 0.90 ADORA2A (0.53) ADORA2AADORA1ADORA3ALDH1A1SMN1; SMN2
SCHEMBL12661727 0.90 ADORA2A (0.53) ADORA2AADORA1ADORA3ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4121419-B1 COCRYSTALS OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCARBAMOYL)CYCLOPENTANE CARBOXYLIC ACID PALOBIOFARMA SL (ES) 2024-08-14 EP claimed
EP-3592734-B1 AMINE SALT OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCARBAMOYL)CYCLOPENTANE CARBOXYLIC ACID PALOBIOFARMA SL (ES) 2021-05-19 EP claimed
EP-2197860-B1 NEW COMPOUNDS AS ADENOSINE A1 RECEPTOR ANTAGONISTS PALOBIOFARMA SL (ES) 2011-05-25 EP claimed
EP-4199922-B1 (1R,3S)-3-((5-CYANO-4-PHENYLTHIAZOL-2-YL)CARBAMOYL)CYCLOPENTANE-1-CARBOXYLIC ACID FOR USE IN THE TREATMENT OF AIRWAY DISEASES PALOBIOFARMA SL (ES) 2024-09-25 EP disclosed
EP-4121419-B1 COCRYSTALS OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCARBAMOYL)CYCLOPENTANE CARBOXYLIC ACID PALOBIOFARMA SL (ES) 2024-08-14 EP disclosed
EP-4199922-A1 (1R,3S)-3-((5-CYANO-4-PHENYLTHIAZOL-2-YL)CARBAMOYL)CYCLOPENTANE-1-CARBOXYLIC ACID AND DERIVATIVES THEREOF FOR USE IN THE TREATMENT OF AIRWAY DISEASES Palobiofarma, S.L. (ES) 2023-06-28 EP disclosed
US-20230183195-A1 COCRYSTALS OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCARBAMOYL)CYCLOPENTANE CARBOXYLIC ACID PALOBIOFARMA, S.L. (ES) 2023-06-15 US disclosed
EP-4121419-A1 COCRYSTALS OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCABAMOYL)CYCLOPENTANE CARBOXYLIC ACID Palobiofarma, S.L. (ES) 2023-01-25 EP disclosed
EP-4121419-A1 COCRYSTALS OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCABAMOYL)CYCLOPENTANE CARBOXYLIC ACID Palobiofarma, S.L. (ES) 2023-01-25 EP disclosed
EP-4121419-A1 COCRYSTALS OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCABAMOYL)CYCLOPENTANE CARBOXYLIC ACID Palobiofarma, S.L. (ES) 2023-01-25 EP disclosed
EP-3957308-A1 (1R,3S)-3-((5-CYANO-4-PHENYLTHIAZOL-2-YL)CARBAMOYL)CYCLOPENTANE-1-CARBOXYLIC ACID AND DERIVATIVES THEREOF FOR USE IN THE TREATMENT OF AIRWAY DISEASES Palobiofarma, S.L. (ES) 2022-02-23 EP disclosed
WO-2021185748-A1 COCRYSTALS OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCABAMOYL)CYCLOPENTANE CARBOXYLIC ACID PALOBIOFARMA, S.L. (ES) 2021-09-23 WO disclosed
WO-2021185748-A1 COCRYSTALS OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCABAMOYL)CYCLOPENTANE CARBOXYLIC ACID PALOBIOFARMA, S.L. (ES) 2021-09-23 WO disclosed
EP-3882240-A1 COCRYSTALS OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCABAMOYL)CYCLOPENTANE CARBOXYLIC ACID Palobiofarma, S.L. (ES) 2021-09-22 EP disclosed
EP-3882240-A1 COCRYSTALS OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCABAMOYL)CYCLOPENTANE CARBOXYLIC ACID Palobiofarma, S.L. (ES) 2021-09-22 EP disclosed
EP-3592734-B1 AMINE SALT OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCARBAMOYL)CYCLOPENTANE CARBOXYLIC ACID PALOBIOFARMA SL (ES) 2021-05-19 EP disclosed
EP-3592734-B1 AMINE SALT OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCARBAMOYL)CYCLOPENTANE CARBOXYLIC ACID PALOBIOFARMA SL (ES) 2021-05-19 EP disclosed
US-10583127-B2 Amine salt of (1R, 3S)-3-(5-cyano-4-phenyl-1,3- thiazol-2-ylcarbamoyl)cyclopentane carboxylic acid PALOBIOFARMA, S.L. (ES) 2020-03-10 US disclosed
US-8410282-B2 Compounds as adenosine A1 receptor antagonists PALOBIOFARMA, S.L. (ES) 2013-04-02 US disclosed
US-20100311703-A1 NEW COMPOUNDS AS ADENOSINE A1 RECEPTOR ANTAGONISTS PALOBIOFARMA, S.L. (ES) 2010-12-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10583127-B2 Amine salt of (1R, 3S)-3-(5-cyano-4-phenyl-1,3- thiazol-2-ylcarbamoyl)cyclopentane carboxylic acid ADORA1, ADORA2A, ADORA3 ADORA2A 2/4885ADORA1 1/4885ADORA3 3/4885
US-20230183195-A1 COCRYSTALS OF (1R,3S)-3-(5-CYANO-4-PHENYL-1,3-THIAZOL-2-YLCARBAMOYL)CYCLOPENTANE CARBOXYLIC ACID ADORA1, ADORA2A, ADORA3 ADORA2A 2/4885ADORA1 1/4885ADORA3 3/4885
US-20100311703-A1 NEW COMPOUNDS AS ADENOSINE A1 RECEPTOR ANTAGONISTS ADORA1, ADORA2A, ADORA3 ADORA2A 2/4885ADORA1 1/4885ADORA3 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.