Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838807 | 0.88 | PPM1D (0.32) | PPM1D | |
| SCHEMBL838808 | 0.88 | PPM1D (0.32) | PPM1D | |
| SCHEMBL838814 | 0.85 | PPM1D (0.35) | PPM1DMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3126788 | 0.85 | PPM1D (0.35) | PPM1DMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL839438 | 0.74 | GCK (0.38) | — | |
| SCHEMBL839439 | 0.74 | GCK (0.38) | — | |
| SCHEMBL838685 | 0.73 | RAB9A (0.40) | MEN1KMT2AMAPT | |
| SCHEMBL840380 | 0.73 | RAB9A (0.42) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL840379 | 0.73 | RAB9A (0.42) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL838686 | 0.73 | RAB9A (0.40) | MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010015849-A2 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-02-11 | — | — | WO | disclosed |