Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | PDGFA | P04085 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1846930 | 0.92 | ADORA3 (0.53) | JAK2BRAFKDRADORA3ADORA2A | |
| SCHEMBL1854861 | 0.90 | ADORA3 (0.48) | JAK2BRAFKDRADORA3RXFP1 | |
| SCHEMBL3775335 | 0.90 | ADORA3 (0.48) | JAK2BRAFKDRADORA3RXFP1 | |
| SCHEMBL1854145 | 0.90 | ADORA3 (0.48) | JAK2BRAFKDRADORA3RXFP1 | |
| SCHEMBL3770544 | 0.88 | KDR (0.47) | JAK2BRAFKDRADORA3ADORA2A | |
| SCHEMBL1848588 | 0.87 | ADORA3 (0.58) | ADORA3ADORA2AADORA1GSK3BKDM4E | |
| SCHEMBL3764638 | 0.86 | BRAF (0.42) | JAK2BRAFKDRADORA3RXFP1 | |
| SCHEMBL1847530 | 0.86 | ADORA3 (0.59) | ADORA3ADORA2AADORA1GSK3BKDM4E | |
| SCHEMBL1848517 | 0.85 | KMT2A (0.48) | JAK2ADORA3ADORA2AADORA1GSK3B | |
| SCHEMBL1849615 | 0.85 | MAPK14 (0.53) | ADORA3ADORA2AADORA1MAPK14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197860-B1 | NEW COMPOUNDS AS ADENOSINE A1 RECEPTOR ANTAGONISTS | PALOBIOFARMA SL (ES) | 2011-05-25 | — | — | EP | claimed |