Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 10/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30864016 | 0.81 | USP2 (0.44) | USP2SMN1; SMN2MGLLRECQLHPGD | |
| SCHEMBL20411385 | 0.80 | USP2 (0.46) | USP2SMN1; SMN2MGLLRECQLHPGD | |
| SCHEMBL20411386 | 0.80 | USP2 (0.46) | USP2SMN1; SMN2MGLLRECQLHPGD | |
| SCHEMBL16419553 | 0.80 | USP2 (0.46) | USP2SMN1; SMN2MGLLRECQLHPGD | |
| SCHEMBL18481140 | 0.80 | USP2 (0.46) | USP2SMN1; SMN2MGLLRECQLHPGD | |
| SCHEMBL897951 | 0.80 | USP2 (0.46) | USP2SMN1; SMN2MGLLRECQLHPGD | |
| SCHEMBL30970058 | 0.79 | USP2 (0.45) | USP2SMN1; SMN2MGLLRECQLHPGD | |
| SCHEMBL18418154 | 0.79 | USP2 (0.45) | USP2SMN1; SMN2MGLLRECQLHPGD | |
| SCHEMBL2428569 | 0.79 | USP2 (0.45) | USP2SMN1; SMN2MGLLRECQLHPGD | |
| SCHEMBL18418308 | 0.79 | USP2 (0.45) | USP2SMN1; SMN2MGLLRECQLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328849-B9 | 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS | PFIZER (US) | 2021-01-06 | — | — | EP | disclosed |
| EP-3328849-B1 | 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS | PFIZER (US) | 2020-09-09 | — | — | EP | disclosed |
| WO-2017021805-A1 | 1,1,1-TRIFLUORO-3-HYDROXYPROPAN-2-YL CARBAMATE DERIVATIVES AND 1,1,1-TRIFLUORO-4-HYDROXYBUTAN-2-YL CARBAMATE DERIVATIVES AS MAGL INHIBITORS | PFIZER INC. (US) | 2017-02-09 | — | — | WO | disclosed |