Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1848329 | 1.00 | HTR7 (0.45) | HTR7POLBHTR2ADRD2HTR2C | |
| SCHEMBL757204 | 1.00 | HTR7 (0.45) | HTR7POLBHTR2ADRD2HTR2C | |
| SCHEMBL735893 | 0.95 | POLB (0.44) | HTR7POLBHTR2AHTR2CHTR1A | |
| SCHEMBL735892 | 0.95 | POLB (0.44) | HTR7POLBHTR2AHTR2CHTR1A | |
| SCHEMBL736360 | 0.91 | HTR7 (0.48) | HTR7HTR2ADRD2HTR1A | |
| SCHEMBL736362 | 0.91 | HTR7 (0.48) | HTR7HTR2ADRD2HTR1A | |
| SCHEMBL736361 | 0.91 | HTR7 (0.48) | HTR7HTR2ADRD2HTR1A | |
| SCHEMBL734372 | 0.88 | HTR7 (0.50) | HTR7POLBHTR2ADRD2HTR1A | |
| SCHEMBL734866 | 0.87 | HTR7 (0.43) | HTR7POLBHTR2ADRD2 | |
| SCHEMBL734865 | 0.87 | HTR7 (0.43) | HTR7POLBHTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321285-A1 | DIAZEPAN AND PIPERAZINE DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010012619-A1 | DIAZEPAN AND PIPERAZINE DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-02-04 | — | — | WO | disclosed |