Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 16/20 | 0.51 |
| ▸ | CLK3 | P49761 | 16/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 16/20 | 0.51 |
| ▸ | WNT1 | P04628 | 3/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18493959 | 0.91 | CLK2 (0.63) | CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL18452934 | 0.90 | CLK2 (0.64) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL18487482 | 0.90 | CLK2 (0.59) | CLK2CLK3DYRK1AWNT1ITK | |
| SCHEMBL18482391 | 0.90 | CLK2 (0.54) | CLK2CLK3DYRK1AITK | |
| SCHEMBL18482867 | 0.89 | CLK2 (0.47) | CLK2CLK3DYRK1AWNT1ITK | |
| SCHEMBL18494677 | 0.86 | CLK2 (0.69) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL18482637 | 0.86 | CLK2 (0.56) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL18482865 | 0.85 | CLK2 (0.52) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL18453364 | 0.85 | CLK2 (0.56) | CLK2CLK3DYRK1AWNT1ITK | |
| SCHEMBL18483427 | 0.84 | CLK2 (0.54) | CLK2CLK3DYRK1AWNT1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017023973-A1 | 3-(1H-INDOL-2-YL)-1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED, LLC. (US) | 2017-02-09 | — | — | WO | disclosed |