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SCHEMBL18486299

SCHEMBL18486299

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(-c5cccc(CCC(=O)O)c5)ncnc43)C[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ TYMP P19971 7/20 0.52
▸ DNPH1 O43598 10/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18486323 0.91 TYMP (0.54) TYMPDNPH1
SCHEMBL18486313 0.90 TYMP (0.47) TYMPDNPH1
SCHEMBL18486389 0.90 TYMP (0.42) TYMPDNPH1
SCHEMBL18486366 0.89 TYMP (0.57) TYMPDNPH1
SCHEMBL19689065 0.88 TYMP (0.55) TYMPDNPH1
SCHEMBL18486261 0.85 TYMP (0.56) TYMPDNPH1
SCHEMBL18486295 0.85 TYMP (0.56) TYMPDNPH1
SCHEMBL18486324 0.84 TYMP (0.40) TYMPDNPH1
SCHEMBL18486396 0.83 TYMP (0.36) TYMPDNPH1
SCHEMBL19699220 0.82 DNPH1 (0.59) DNPH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3130597-A1 OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF Kyowa Hakko Kirin Co., Ltd. (JP) 2017-02-15 — — EP disclosed