Sugi Predict

Sugi Predict / Targets / DNPH1

DNPH1

5-hydroxymethyl-dUMP N-hydrolase · O43598 · DNPH1 on Sugi Atlas →

13,960 patent compounds predicted against DNPH1, 11,297 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL198136 SCHEMBL198136 0.69 14/20
SCHEMBL19255 SCHEMBL19255 0.79 11/20
SCHEMBL161318 SCHEMBL161318 0.79 11/20
Thioinosine Monophosphate Thioinosine Monophosphate (SCHEMBL379365) 0.77 11/20
Thioinosine Monophosphate Thioinosine Monophosphate (SCHEMBL379366) 0.77 11/20
SCHEMBL622623 SCHEMBL622623 0.77 11/20
SCHEMBL888031 SCHEMBL888031 0.77 11/20
SCHEMBL621685 SCHEMBL621685 0.77 10/20
SCHEMBL888027 SCHEMBL888027 0.77 10/20
SCHEMBL620523 SCHEMBL620523 0.73 10/20
SCHEMBL1021625 SCHEMBL1021625 0.67 10/20
SCHEMBL939116 SCHEMBL939116 0.70 9/20
SCHEMBL441647 SCHEMBL441647 0.63 8/20
SCHEMBL218771 SCHEMBL218771 0.70 7/20
SCHEMBL901278 SCHEMBL901278 0.57 7/20
SCHEMBL188740 SCHEMBL188740 0.66 6/20
Adenosine Phosphate Adenosine Phosphate (SCHEMBL810818) 0.75 5/20
SCHEMBL621803 SCHEMBL621803 0.72 5/20
SCHEMBL216645 SCHEMBL216645 0.69 5/20
SCHEMBL537998 SCHEMBL537998 0.56 5/20

Clinical trials — most relevant to DNPH1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment PHASE4RECRUITING
Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitors on Sarcopenia in Hemodialysis Patients PHASE4NOT_YET_RECRUITING
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes PHASE2UNKNOWN
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation PHASE2UNKNOWN
Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus PHASE2COMPLETED
IDH2 (AG 221) Inhibitor in Patients With IDH2 Mutated Myelodysplastic Syndrome PHASE2ACTIVE_NOT_RECRUITING
IDH1 (AG 120) Inhibitor in Patients With IDH1 Mutated Myelodysplastic Syndrome PHASE2ACTIVE_NOT_RECRUITING
Pharmacogenomic and Pharmacokinetic Safety and Cost-saving Analysis in Patients Treated With Fluoropyrimidines PHASE1COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
The Role of Transthoracic Echocardiography in Diagnosis of Pulmonary Hypertension of Infants With Bronchopulmonary Dysplasia nanCOMPLETED
The Effects of Oral Fructanase Administration on Gastrointestinal Symptoms After Inulin Challenge in Healthy Adults nanCOMPLETED
Expression of TET1 Gene in Acute Leukaemia nanUNKNOWN
Implementation and Quality Assurance of DPYD-genotyping in Patients Treated With Fluoropyrimidines. nanCOMPLETED
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease nanUNKNOWN
Replacement of Vitamin D in Patients With Active Tuberculosis nanCOMPLETED
Screening of Lysosomal Storage Disorders Diseases in Minority Groups nanUNKNOWN
Mutation Analysis of 17α-Hydroxylase nanUNKNOWN
Ovarian Reserve and Matrix Metalloproteinases nanCOMPLETED
Biomarkers in Exhaled Breath Condensates in Acute Lung Injury: Early Detection and Outcome Predictors nanUNKNOWN
Biomarker for Hypophosphatasia Disease (BioHypophos) nanWITHDRAWN
Oxidative Stress Parameters, Trace Element and Quality of Life in Men Before and After Covid-19 Vaccines nanUNKNOWN
The Effect of REgulation of PArathyroId hoRmone in Patients With Chronic Kidney Disease to Investigate the Change in Bone Mineral Density nanRECRUITING
Algal Lutein Against Decline of Intellectual Nimbleness nanNOT_YET_RECRUITING
Blood Sample Measurements and Physical Activity Levels in Type II Diabetes and/or COVID-19 nanUNKNOWN
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics) nanCOMPLETED
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte nanCOMPLETED
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients nanRECRUITING
Polycystic Ovary Syndrome in Type 1 Diabetes nanNOT_YET_RECRUITING
Value of Butyrylcholinesterase as a Marker of Surgical Site Infection Following Surgery for Colorectal Diseases nanCOMPLETED
Hormonal Regulation of Puberty and Fertility nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a DNPH1 binder may also engage these)

ProteinNameSimilarity
Q80VJ3 — 0.985 Q80VJ3 →
O35820 — 0.984 O35820 →
P38035 — 0.948 P38035 →
Q4S2L4 — 0.946 Q4S2L4 →
C1BW56 — 0.940 C1BW56 →
E9Q4Z2 — 0.939 E9Q4Z2 →
Q5F336 — 0.939 Q5F336 →
Q7W2B5 — 0.937 Q7W2B5 →
Q08BW6 — 0.936 Q08BW6 →
D1A2T1 — 0.936 D1A2T1 →
Q9BXI3 — 0.936 Q9BXI3 →
O95954 — 0.935 O95954 →
Q7WR83 — 0.935 Q7WR83 →
B9JML7 — 0.935 B9JML7 →
A0LU53 — 0.935 A0LU53 →
Q5E9S8 — 0.935 Q5E9S8 →
C1DMT1 — 0.934 C1DMT1 →
ACACB Acetyl-CoA carboxylase 2 0.934 landscape →
Q7VT92 — 0.934 Q7VT92 →
Q8BL86 — 0.934 Q8BL86 →
D2ATU8 — 0.934 D2ATU8 →
Q9Y2V0 — 0.934 Q9Y2V0 →
P10503 — 0.934 P10503 →
Q9ZIG2 — 0.934 Q9ZIG2 →
P9WFP9 — 0.933 P9WFP9 →
B5R6A2 — 0.933 B5R6A2 →
B5QWT7 — 0.933 B5QWT7 →
B5FUB4 — 0.933 B5FUB4 →
Q3U4G0 — 0.933 Q3U4G0 →
O88618 — 0.933 O88618 →