Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196063 | 0.88 | RXFP1 (0.60) | RXFP1MAPTNPC1RAB9AGAA | |
| SCHEMBL1976142 | 0.88 | RXFP1 (0.53) | RXFP1MAPTNPC1RAB9AGAA | |
| SCHEMBL196744 | 0.87 | MAPT (0.58) | RXFP1MAPTNPC1RAB9AGAA | |
| SCHEMBL935627 | 0.86 | RXFP1 (0.51) | RXFP1MAPTNPC1RAB9AGAA | |
| SCHEMBL196512 | 0.85 | MAPT (0.55) | RXFP1MAPTNPC1RAB9AGAA | |
| SCHEMBL196681 | 0.85 | RXFP1 (0.53) | RXFP1MAPTNPC1RAB9AGAA | |
| SCHEMBL934924 | 0.84 | IGF1R (0.52) | RXFP1MAPTNPC1RAB9AGAA | |
| SCHEMBL937298 | 0.84 | MAPT (0.64) | MAPTRAB9ALMNAHTTSMN1; SMN2 | |
| SCHEMBL29501836 | 0.82 | GRM4 (0.51) | RXFP1MAPTNPC1RAB9AGAA | |
| SCHEMBL30637139 | 0.82 | GRM4 (0.51) | RXFP1MAPTNPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323661-A1 | A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS | Universiteit Leiden (NL) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010020981-A1 | A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS | UNIVERSITEIT LEIDEN (NL) | 2010-02-25 | — | — | WO | disclosed |