Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14425319 | 0.93 | DRD4 (0.56) | HPGDEPHX2DRD4CACNA1HALDH1A1 | |
| SCHEMBL5366013 | 0.93 | DRD4 (0.56) | HPGDEPHX2DRD4CACNA1HALDH1A1 | |
| SCHEMBL14425331 | 0.90 | EPHX2 (0.47) | HPGDEPHX2DRD4ALDH1A1KDM4E | |
| SCHEMBL5365324 | 0.90 | CCR3 (0.49) | HPGDEPHX2DRD4CACNA1HALDH1A1 | |
| SCHEMBL14425334 | 0.88 | NPC1L1 (0.45) | HPGDEPHX2DRD4CACNA1HALDH1A1 | |
| SCHEMBL5366509 | 0.87 | SMN1; SMN2 (0.58) | HPGDEPHX2DRD4CACNA1HALDH1A1 | |
| SCHEMBL5368664 | 0.87 | DRD4 (0.54) | HPGDEPHX2DRD4CACNA1HALDH1A1 | |
| SCHEMBL5360176 | 0.87 | HPGD (0.45) | HPGDEPHX2DRD4CACNA1HALDH1A1 | |
| SCHEMBL5368583 | 0.87 | EPHX2 (0.48) | HPGDEPHX2DRD4CACNA1HALDH1A1 | |
| SCHEMBL5360946 | 0.86 | EPHX2 (0.47) | HPGDEPHX2DRD4CACNA1HALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |