Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ESRRG | P62508 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5360946 | 0.90 | EPHX2 (0.47) | EPHX2HPGDKDM4EALDH1A1GAA | |
| SCHEMBL5366013 | 0.87 | DRD4 (0.56) | EPHX2HPGDKDM4EALDH1A1GAA | |
| SCHEMBL14425319 | 0.87 | DRD4 (0.56) | EPHX2HPGDKDM4EALDH1A1GAA | |
| SCHEMBL18487141 | 0.87 | HPGD (0.55) | EPHX2HPGDKDM4EALDH1A1GAA | |
| SCHEMBL5360176 | 0.83 | HPGD (0.45) | EPHX2HPGDKDM4EALDH1A1GAA | |
| SCHEMBL5365324 | 0.82 | CCR3 (0.49) | EPHX2HPGDKDM4EALDH1A1GAA | |
| SCHEMBL5368664 | 0.81 | DRD4 (0.54) | EPHX2HPGDKDM4EALDH1A1GAA | |
| SCHEMBL5366509 | 0.81 | SMN1; SMN2 (0.58) | EPHX2HPGDKDM4EALDH1A1GAA | |
| SCHEMBL14425328 | 0.81 | KDM4E (0.53) | EPHX2HPGDKDM4EALDH1A1GAA | |
| SCHEMBL5374908 | 0.80 | ENPP2 (0.48) | EPHX2HPGDPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |