Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 10/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14820137 | 0.83 | HCAR2 (0.55) | HCAR2 | |
| SCHEMBL14805628 | 0.79 | HCAR2 (0.55) | HCAR2 | |
| SCHEMBL6014115 | 0.74 | HCAR2 (0.59) | HCAR2 | |
| SCHEMBL11794359 | 0.73 | HCAR2 (0.61) | HCAR2 | |
| SCHEMBL10984818 | 0.71 | HCAR2 (0.59) | HCAR2 | |
| SCHEMBL20954965 | 0.71 | HCAR2 (0.59) | HCAR2 | |
| SCHEMBL26017631 | 0.71 | HCAR2 (0.59) | HCAR2 | |
| SCHEMBL11781060 | 0.71 | HCAR2 (0.59) | HCAR2 | |
| SCHEMBL11578825 | 0.71 | HCAR2 (0.62) | HCAR2 | |
| SCHEMBL11667578 | 0.69 | HCAR2 (0.56) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170037059-A1 | GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037059-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | ALDH1A1 2837/4885HCAR2 2341/4885TP53 3289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.