Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 9/20 | 0.84 |
| ▸ | CDK9 | P50750 | 9/20 | 0.84 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.84 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.84 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.69 |
| ▸ | CDK2 | P24941 | 8/20 | 0.69 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 7/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meriolin 7 SCHEMBL2239805 | 0.92 | CCNT1 (1.00) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| Meriolin 7 SCHEMBL31061600 | 0.92 | CCNT1 (1.00) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| Meriolin 5 SCHEMBL2997013 | 0.82 | CDK5 (1.00) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| Meriolin 1 SCHEMBL2241315 | 0.81 | CDK9 (1.00) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL2994949 | 0.81 | CCNT1 (0.89) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL2992869 | 0.80 | CDK5 (0.87) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL1836044 | 0.80 | CDK5 (0.78) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| SCHEMBL2992879 | 0.80 | CDK5 (0.78) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| Meriolin 4 SCHEMBL3001373 | 0.79 | CDK5 (1.00) | CCNT1CDK9CDK5CDK5R1CCNA2 | |
| Meriolin 4 SCHEMBL31061625 | 0.79 | CDK5 (1.00) | CCNT1CDK9CDK5CDK5R1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320895-A2 | CDK MODULATORS | Exelixis, Inc. (US) | 2011-05-18 | — | — | EP | claimed |