Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 6/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9892989 | 0.81 | FPR1 (0.44) | CNR2CYP2C8CYP2D6CNR1CYP2C19 | |
| SCHEMBL28845226 | 0.80 | AR (0.39) | KMT2ADRD3DRD2 | |
| SCHEMBL16480461 | 0.75 | AR (0.50) | CNR2CYP2C8CYP2D6CNR1CYP2C19 | |
| SCHEMBL18490902 | 0.74 | HRH3 (0.42) | MAPTALDH1A1MAPK1NOTUM | |
| SCHEMBL18490893 | 0.74 | HRH3 (0.42) | MAPTALDH1A1MAPK1NOTUM | |
| SCHEMBL18488068 | 0.73 | AKR1C3 (0.38) | MAPTDRD3DRD2KCNH2 | |
| SCHEMBL9891844 | 0.73 | CNR2 (0.45) | CNR2CYP2C8CYP2D6CNR1CYP2C19 | |
| SCHEMBL21136651 | 0.72 | BRD4 (0.50) | CNR2CYP2C8CYP2D6CNR1CYP2C19 | |
| SCHEMBL18013246 | 0.72 | BRD4 (0.50) | CNR2CYP2C8CYP2D6CNR1CYP2C19 | |
| SCHEMBL20668703 | 0.71 | FPR1 (0.58) | CNR2FPR1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331886-B1 | DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY | INDIVIOR UK LTD (GB) | 2020-07-15 | — | — | EP | disclosed |
| WO-2017021920-A1 | DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY | INDIVIOR UK LIMITED (GB) | 2017-02-09 | — | — | WO | disclosed |