SCHEMBL1848946

SCHEMBL1848946

CC(C)(C)OC(=O)N1CC(F)(F)C[C@@H]1C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.41
HDAC8 Q9BY41 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
CHRM2 P08172 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34
EPHX2 P34913 1/20 0.34
USP2 O75604 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL193268 1.00 HSD17B10 (0.41) HSD17B10HDAC8SMN1; SMN2CHRM2CHRM1
SCHEMBL185992 1.00 HSD17B10 (0.41) HSD17B10HDAC8SMN1; SMN2CHRM2CHRM1
SCHEMBL15116535 0.88 HDAC8 (0.37) HSD17B10HDAC8SMN1; SMN2CHRM2CHRM1
SCHEMBL19484832 0.88 HDAC8 (0.37) HSD17B10HDAC8SMN1; SMN2CHRM2CHRM1
SCHEMBL13059379 0.88 HDAC8 (0.37) HSD17B10HDAC8SMN1; SMN2CHRM2CHRM1
SCHEMBL19389888 0.88 HDAC8 (0.37) HSD17B10HDAC8SMN1; SMN2CHRM2CHRM1
SCHEMBL6468015 0.86 CNR2 (0.39) HSD17B10HDAC8CHRM2CHRM1CHRM3
SCHEMBL15130409 0.86 CNR2 (0.39) HSD17B10HDAC8CHRM2CHRM1CHRM3
SCHEMBL19131812 0.86 HSD17B10 (0.37) HSD17B10HDAC8SMN1; SMN2CHRM2CHRM1
SCHEMBL1347670 0.86 CNR2 (0.39) HSD17B10HDAC8CHRM2CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122094953-A 1, 3-Dihydro-2H-pyrrolo [3,4-c ] quinoline derivatives as cGAS inhibitors for the treatment of inflammatory and/or autoimmune diseases 2026-05-26 CN disclosed
WO-2026103887-A1 PROLINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF 北京康辰药业股份有限公司 2026-05-21 WO disclosed
EP-4695236-A1 SUBSTITUTED PHENYL-PIPERAZINYL BASED MODULATORS FOR THE TREATMENT OF DISEASE Soley Therapeutics, Inc. (US) 2026-02-18 EP disclosed
EP-4608821-A1 PHARMACEUTICAL COMPOUNDS AS PARP7 AND/OR PARP1 INHIBITORS Duke Street Bio Limited (GB) 2025-09-03 EP disclosed
WO-2025090774-A1 CHEMOTHERAPEUTIC COMPOUNDS AND METHODS OF USE SEAGEN INC. (US) 2025-05-01 WO disclosed
WO-2025040569-A1 1,3-DIHYDRO-2H-PYRROLO[3,4-C]QUINOLINE DERIVATIVES AS CGAS INHIBITORS FOR THE TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE DISEASES KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2025-02-27 WO disclosed
CN-114591212-B Human plasma kallikrein inhibitors 拜奥克里斯特制药公司 2025-01-28 CN disclosed
WO-2024216094-A1 SUBSTITUTED PHENYL-PIPERAZINYL BASED MODULATORS FOR THE TREATMENT OF DISEASE SOLEY THERAPEUTICS, INC. (US) 2024-10-17 WO disclosed
WO-2024115465-A1 PHARMACEUTICAL COMPOUNDS AS PARP7 AND/OR PARP1 INHIBITORS Duke Street Bio Limited (GB) 2024-06-06 WO disclosed
WO-2024107778-A1 NOVEL PROTEASE INHIBITORS FOR TREATMENT OF CORONAVIRUS INFECTIONS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-05-23 WO disclosed
US-20160272585-A1 Phenoxyethyl Cyclic Amine Derivatives and Their Activity as EP4 Receptor Modulators ELI LILLY AND COMPANY (US) 2016-09-22 US disclosed
US-20160272585-A1 Phenoxyethyl Cyclic Amine Derivatives and Their Activity as EP4 Receptor Modulators ELI LILLY AND COMPANY (US) 2016-09-22 US disclosed
WO-2015094902-A1 PHENOXYETHYL CYCLIC AMINE DERIVATIVES AND THEIR ACTIVITY AS EP4 RECEPTOR MODULATORS ELI LILLY AND COMPANY (US) 2015-06-25 WO disclosed
US-20140221332-A1 METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF SUNOVION PHARMACEUTICALS INC. (US) 2014-08-07 US disclosed
US-20140221332-A1 METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF SUNOVION PHARMACEUTICALS INC. (US) 2014-08-07 US disclosed
US-20140221332-A1 METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF SUNOVION PHARMACEUTICALS INC. (US) 2014-08-07 US disclosed
WO-2012162635-A1 METABOTROPIC GLUTAMATE RECEPTORS 5 MODULATORS AND METHODS OF USE THEREOF SUNOVION PHARMACEUTICALS INC. (US) 2012-11-29 WO disclosed
WO-2012054510-A1 OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2012-04-26 WO disclosed
EP-2097419-B1 BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS EXELIXIS INC (US) 2011-05-25 EP disclosed
US-20090247559-A1 Benzofuropyrimidinones EXELIXIS, INC. (US) 2009-10-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160272585-A1 Phenoxyethyl Cyclic Amine Derivatives and Their Activity as EP4 Receptor Modulators PTGER4, PTGER1, GPR4 HSD17B10 3686/4885HDAC8 938/4885SMN1; SMN2 4442/4885
US-20140221332-A1 METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF GRM5, GRIK5, GRM2 HSD17B10 1045/4885HDAC8 1998/4885SMN1; SMN2 2960/4885
US-20090247559-A1 Benzofuropyrimidinones F12, BRI3BP, BRD1 HSD17B10 1290/4885HDAC8 1523/4885SMN1; SMN2 1926/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.