GPR4

G-prodeshotein coupled receptor 4 · P46093 · GPR4 on Sugi Atlas →

2,680 patent compounds predicted against GPR4, 1,617 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4374334	1.00	19/20
SCHEMBL4374338	1.00	19/20
SCHEMBL4371048	0.73	19/20
SCHEMBL4371050	0.73	19/20
Hydrochloric Acid (SCHEMBL4374356)	0.72	19/20
SCHEMBL4369325	0.69	19/20
SCHEMBL4369327	0.69	19/20
SCHEMBL4330744	0.61	19/20
SCHEMBL4330749	0.61	19/20
SCHEMBL4366915	0.55	19/20
SCHEMBL4366919	0.55	19/20
SCHEMBL4366684	0.54	19/20
SCHEMBL4366687	0.54	19/20
Hydrochloric Acid (SCHEMBL4373396)	0.54	19/20
Hydrochloric Acid (SCHEMBL4373399)	0.54	19/20
Hydrochloric Acid (SCHEMBL4373414)	0.53	19/20
Hydrochloric Acid (SCHEMBL4373419)	0.53	19/20
SCHEMBL4361181	0.53	18/20
SCHEMBL4361185	0.53	18/20
Hydrochloric Acid (SCHEMBL4324719)	0.53	18/20

Clinical trials — most relevant to GPR4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
Montelukast in Parkinson Disease	PHASE2/PHASE3	RECRUITING
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Investigation the Effect of Montelukast in COVID-19	PHASE2	UNKNOWN
Mediterranean Diet and Inequality in Early Breast Cancer	PHASE2	RECRUITING
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Selective β2-AR Antagonism in Asthma	PHASE1	COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate Receptors	nan	UNKNOWN
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Gastroparesis Registry 3	nan	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis	nan	WITHDRAWN
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
Precision Medicine for Nociception, Sngception and Proprioception.	nan	RECRUITING
Colonic Propionate, Appetite, and Weight Loss	nan	COMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling	nan	COMPLETED
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis	nan	COMPLETED
The Natural History of TRPV4 Neuropathy	nan	RECRUITING
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins	nan	COMPLETED
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Investigation of the Pruritogens of Liver-related Diseases	nan	UNKNOWN
The Role of Autoantibodies Against G-protein Coupled Receptors in Obesity	nan	NOT_YET_RECRUITING
Gut Microbiota and Modulation of Liver Damage in NAFLD	nan	COMPLETED
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GPR4 binder may also engage these)

Protein	Name	Similarity
Q8BUD0	—	1.000	Q8BUD0 →
Q4KLH9	—	1.000	Q4KLH9 →
P50132	—	1.000	P50132 →
Q1JQB3	—	1.000	Q1JQB3 →
O46685	—	0.993	O46685 →
GPR68	G-protein coupled receptor 68	0.991	landscape →
Q8BFQ3	—	0.989	Q8BFQ3 →
A0A4W3GG95	—	0.988	A0A4W3GG95 →
GPR132	Probable G-protein coupled receptor 132	0.987	landscape →
E7FEL0	—	0.985	E7FEL0 →
Q9Z282	—	0.985	Q9Z282 →
Q9GLX8	—	0.979	Q9GLX8 →
O88855	—	0.978	O88855 →
Q28642	—	0.977	Q28642 →
FFAR2	Free fatty acid receptor 2	0.976	landscape →
Q9R0Q2	—	0.975	Q9R0Q2 →
Q8C131	—	0.974	Q8C131 →
Q8BLG2	—	0.973	Q8BLG2 →
Q3UFD7	—	0.973	Q3UFD7 →
P25023	—	0.973	P25023 →
Q8BFU7	—	0.972	Q8BFU7 →
O70526	—	0.972	O70526 →
Q8VCK6	—	0.972	Q8VCK6 →
B2GV46	—	0.972	B2GV46 →
FFAR3	Free fatty acid receptor 3	0.972	landscape →
P32299	—	0.971	P32299 →
O15529	—	0.971	O15529 →
HCAR2	Hydroxycarboxylic acid receptor 2	0.971	landscape →
P31392	—	0.971	P31392 →
A7YY44	—	0.970	A7YY44 →