Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1353637 | 1.00 | SYK (0.53) | SYK | |
| SCHEMBL1849063 | 0.89 | SYK (0.57) | SYK | |
| SCHEMBL1849058 | 0.89 | SYK (0.57) | SYK | |
| SCHEMBL1849388 | 0.88 | SYK (0.58) | SYK | |
| SCHEMBL1353892 | 0.88 | SYK (0.58) | SYK | |
| SCHEMBL1848964 | 0.87 | SYK (0.53) | SYK | |
| SCHEMBL1848081 | 0.87 | SYK (0.58) | SYK | |
| SCHEMBL1849685 | 0.84 | SYK (0.59) | SYK | |
| SCHEMBL1354628 | 0.84 | SYK (0.59) | SYK | |
| SCHEMBL1853033 | 0.83 | SYK (0.61) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323993-B1 | 2,6-DIAMINO- PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS | PORTOLA PHARM INC (US) | 2015-06-03 | — | — | EP | disclosed |
| EP-2323993-A2 | 2,6-DIAMINO- PYRIMIDIN- 5-YL-CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2009136995-A2 | INHIBITORS OF SYK PROTEIN KINASE | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |