Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850947 | 0.75 | FLT3 (0.75) | MIFTEKKDRFLT3GSK3B | |
| SCHEMBL1847540 | 0.74 | FLT3 (0.43) | MIFSMN1; SMN2BCHETEKKDR | |
| SCHEMBL1849056 | 0.74 | MIF (0.74) | MIFFLT3GSK3BMAPK14CA12 | |
| SCHEMBL1850929 | 0.74 | MIF (0.61) | MIFKDRFLT3GSK3BCA12 | |
| SCHEMBL2394519 | 0.73 | MIF (0.73) | MIFTEKKDRFLT3GSK3B | |
| SCHEMBL1847328 | 0.71 | MIF (0.61) | MIFTEKKDRFLT3GSK3B | |
| SCHEMBL1848007 | 0.71 | MIF (0.65) | MIFTEKKDRFLT3GSK3B | |
| SCHEMBL15883329 | 0.71 | MIF (0.61) | MIFFLT3GSK3BCA12CA1 | |
| SCHEMBL4032989 | 0.69 | MIF (0.52) | MIFDPP4NPC1RAB9A | |
| SCHEMBL4033982 | 0.69 | MIF (0.52) | MIFBCHETEKKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-09-01 | — | — | US | claimed |
| CN-102131797-A | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators | NEUROSEARCH AS | 2011-07-20 | — | — | CN | claimed |
| EP-2324007-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NeuroSearch A/S (DK) | 2011-05-25 | — | — | EP | claimed |
| WO-2010026134-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2010-03-11 | — | — | WO | claimed |
| EP-2324007-B1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH AS (DK) | 2012-08-15 | — | — | EP | disclosed |
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-09-01 | — | — | US | disclosed |
| CN-102131797-A | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators | NEUROSEARCH AS | 2011-07-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA3, CHRNA5, CHRNB3 | MIF 2769/4885SMN1; SMN2 762/4885BCHE 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.