CHRNA3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Radafaxine (SCHEMBL48964)	1.00	20/20
SCHEMBL80066	0.65	14/20
Bromide (SCHEMBL69311)	0.62	13/20
SCHEMBL206365	0.50	12/20
SCHEMBL80814	0.72	11/20
Stilonium (SCHEMBL26104)	1.00	10/20
Stilonium (SCHEMBL26105)	1.00	10/20
SCHEMBL165812	0.87	10/20
Cytisinicline (SCHEMBL161398)	1.00	9/20
SCHEMBL80826	0.58	9/20
SCHEMBL201988	0.56	9/20
SCHEMBL232661	0.56	9/20
SCHEMBL81218	0.53	9/20
SCHEMBL81293	0.51	9/20
SCHEMBL218547	0.44	7/20
Altinicline (SCHEMBL194945)	0.79	6/20
SCHEMBL155343	0.65	6/20
SCHEMBL155974	0.65	6/20
SCHEMBL159158	0.64	6/20
SCHEMBL159159	0.64	6/20

Clinical trials — most relevant to CHRNA3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy of the Use of Genetic Markers in the Choice of the Pharmacological Treatment of Smoking (GENTSMOKING)	PHASE4	COMPLETED
Galantamine for Cognition in People With Schizophrenia	PHASE4	COMPLETED
Efficacy Study of Galantamine for Cognitive Impairments in Schizophrenia	PHASE4	COMPLETED
Postoperative Sugammadex After COVID-19	PHASE4	UNKNOWN
The Efficacy of a Combination Regimen in Patients With Mild to Moderate Probable Alzheimer's Disease	PHASE4	COMPLETED
Transcranial Magnetic Stimulation in Patients with Dual Disorders	PHASE3	NOT_YET_RECRUITING
Safety and Efficacy of MEM 3454 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease Experiments 1 & 2 - Proj #3	PHASE2	COMPLETED
Crossover Target Engagement Study of Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease (Project #3 - Experiment 3 [UdallP3E3])	PHASE2	COMPLETED
Nicotinic Receptors and Schizophrenia	PHASE1/PHASE2	WITHDRAWN
The Effect of Donepezil (Aricept(Registered Trademark)) on REM Sleep in Children With Autism	PHASE1/PHASE2	COMPLETED
Imaging of Brain Receptors in Healthy Volunteers and in Patients With Schizophrenia	PHASE2	COMPLETED
Nicotinic Receptor Augmentation of SSRI Antidepressants	PHASE2	COMPLETED
Effect of Varenicline on Cognitive Function in Cigarette Smokers With Schizophrenia	PHASE2	COMPLETED
Brain Networks and Addiction Susceptibility	PHASE1	COMPLETED
Nicotinic Receptor Genetic Variation and Alcohol Reward	PHASE1	RECRUITING
Gene Therapy for Alzheimer's Disease Clinical Trial	PHASE1	COMPLETED
The Use of AVL-3288 to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine	PHASE1	WITHDRAWN
Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression	nan	COMPLETED
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia	nan	UNKNOWN
Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia	nan	COMPLETED
Effects of Prazosin on the Attention-Enhancing Effects of Nicotine	nan	WITHDRAWN
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN
Nicotinic Receptor Levels After Stopping Smoking	nan	COMPLETED
fMRI Study of Nicotinic Effect on Neurophysiology of Schizophrenia	nan	COMPLETED
Brain Imaging in Alzheimer's Disease	nan	COMPLETED
Preemptive Oral Gabapentin and Tramadol on Postoperative Pain After Knee Arthroscopy	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Non-Invasive Brain Stimulation to Improve Language in Down Syndrome.	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a CHRNA3 binder may also engage these)

Protein	Name	Similarity
P04757	—	1.000	P04757 →
Q8R4G9	—	1.000	Q8R4G9 →
Q07263	—	1.000	Q07263 →
CHRNA6	Neuronal acetylcholine receptor subunit alpha	1.000	landscape →
P49581	—	0.999	P49581 →
Q5IS51	—	0.997	Q5IS51 →
P26152	—	0.997	P26152 →
CHRNA5	Neuronal acetylcholine receptor subunit alpha	0.997	landscape →
P20420	—	0.996	P20420 →
Q2MKA5	—	0.996	Q2MKA5 →
Q5IS75	—	0.996	Q5IS75 →
CHRNB3	Neuronal acetylcholine receptor subunit beta-	0.996	landscape →
P04755	—	0.996	P04755 →
P02710	—	0.995	P02710 →
CHRNA1	Acetylcholine receptor subunit alpha	0.995	landscape →
P25162	—	0.994	P25162 →
Q8SPU7	—	0.994	Q8SPU7 →
P43143	—	0.994	P43143 →
P02711	—	0.994	P02711 →
P12391	—	0.994	P12391 →
Q9N587	—	0.994	Q9N587 →
Q91X60	—	0.993	Q91X60 →
P09481	—	0.993	P09481 →
P43679	—	0.993	P43679 →
Q9R0W9	—	0.993	Q9R0W9 →
O16926	—	0.993	O16926 →
P25108	—	0.993	P25108 →
Q5IS76	—	0.992	Q5IS76 →
P04756	—	0.992	P04756 →
P12389	—	0.992	P12389 →