Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18497731 | 1.00 | IRAK4 (0.46) | IRAK4CHEK2PRMT5PIK3CDPIK3CA | |
| SCHEMBL18525653 | 0.89 | CHEK2 (0.46) | CHEK2PRMT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL18525654 | 0.89 | CHEK2 (0.46) | CHEK2PRMT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL18525645 | 0.86 | IRAK4 (0.62) | IRAK4 | |
| SCHEMBL18525646 | 0.86 | IRAK4 (0.62) | IRAK4 | |
| SCHEMBL18497836 | 0.85 | CHEK2 (0.48) | IRAK4CHEK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL18497837 | 0.85 | CHEK2 (0.48) | IRAK4CHEK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL18497816 | 0.85 | CHEK2 (0.47) | IRAK4CHEK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL18497817 | 0.85 | CHEK2 (0.47) | IRAK4CHEK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL18497822 | 0.81 | IRAK4 (0.59) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017025849-A1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS | PFIZER INC. (US) | 2017-02-16 | — | — | WO | disclosed |