Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HLCS | P50747 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18499747 | 1.00 | CYP19A1 (0.40) | CYP19A1ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL9123924 | 0.84 | CYP19A1 (0.43) | CYP19A1ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3752093 | 0.84 | CYP19A1 (0.43) | CYP19A1ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL10034013 | 0.84 | CYP19A1 (0.43) | CYP19A1ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL11712587 | 0.84 | CYP19A1 (0.43) | CYP19A1ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL8896238 | 0.82 | TSHR (0.39) | CYP19A1ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3753654 | 0.82 | CYP19A1 (0.47) | CYP19A1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5690985 | 0.81 | CYP19A1 (0.50) | CYP19A1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL6675475 | 0.80 | CYP19A1 (0.51) | CYP19A1MEN1KMT2AMGLLPTGS1 | |
| SCHEMBL23518383 | 0.79 | CYP19A1 (0.45) | CYP19A1ALDH1A1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10695433-B2 | Pyrrolobenzodiazepine-antibody conjugates | MEDIMMUNE LIMITED (GB) | 2020-06-30 | — | — | US | disclosed |
| US-10188746-B2 | Pyrrolobenzodiazepines and conjugates thereof | MEDIMMUNE LIMITED (GB) | 2019-01-29 | — | — | US | disclosed |
| US-20170340752-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | MEDIMMUNE LIMITED (GB) | 2017-11-30 | — | — | US | disclosed |
| US-9567340-B2 | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases | MEDIMMUNE LIMITED (GB) | 2017-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10188746-B2 | Pyrrolobenzodiazepines and conjugates thereof | CD22, GABRA1, CCNB1 | CYP19A1 2498/4885ALDH1A1 1275/4885MEN1 1037/4885 |
| US-10695433-B2 | Pyrrolobenzodiazepine-antibody conjugates | IL2RA, CD4, IL2 | CYP19A1 4331/4885ALDH1A1 2032/4885MEN1 3908/4885 |
| US-20170340752-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | CD22, GABRA1, CCNB1 | CYP19A1 2498/4885ALDH1A1 1275/4885MEN1 1037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.