Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 3/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.32 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12286069 | 0.92 | KMT2A (0.48) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12285877 | 0.91 | HDAC3 (0.40) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16895236 | 0.90 | DRD3 (0.38) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12288689 | 0.90 | LMNA (0.41) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10283653 | 0.88 | HDAC3 (0.40) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10295062 | 0.87 | DRD3 (0.40) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12325479 | 0.85 | DRD3 (0.35) | KMT2ADRD3MTNR1AMTNR1B | |
| SCHEMBL15801453 | 0.83 | SMN1; SMN2 (0.39) | DRD3NAMPTMTNR1AMTNR1B | |
| SCHEMBL18588545 | 0.83 | HTT (0.40) | DRD3MTNR1AMTNR1BBCHEACHE | |
| SCHEMBL12284112 | 0.81 | EGFR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9566340-B2 | Monomers and oligonucleotides comprising cycloaddition adduct(s) | ALNYLAM PHARMACEUTICALS, INC. (US) | 2017-02-14 | — | — | US | disclosed |