Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690703 | 0.83 | KDM4E (0.46) | KDM4ETSHRALDH1A1MAPK14HSD17B10 | |
| SCHEMBL17652970 | 0.78 | HTT (0.41) | KDM4ETSHRALDH1A1MAPK14RECQL | |
| SCHEMBL1846611 | 0.77 | MAPK14 (0.63) | MAPK14 | |
| SCHEMBL16106451 | 0.75 | MAPK14 (0.50) | ALDH1A1MAPK14SMN1; SMN2HTT | |
| SCHEMBL16106403 | 0.75 | GSK3A (0.43) | KDM4EALDH1A1MAPK14SMN1; SMN2HTT | |
| SCHEMBL16829462 | 0.75 | MAPK14 (0.39) | KDM4ETSHRALDH1A1MAPK14SMN1; SMN2 | |
| SCHEMBL16829205 | 0.75 | MAPK14 (0.47) | ALDH1A1MAPK14SMN1; SMN2 | |
| SCHEMBL17669672 | 0.75 | MAPK14 (0.49) | KDM4EALDH1A1MAPK14HSD17B10 | |
| SCHEMBL16829286 | 0.74 | GSK3A (0.48) | MAPK14 | |
| SCHEMBL1847413 | 0.74 | MAPK14 (0.39) | TSHRALDH1A1MAPK14SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | claimed |
| WO-2010026096-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | claimed |