Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850153 | 0.83 | KDM4E (0.49) | KDM4EALDH1A1TSHRMAPK14RXFP1 | |
| SCHEMBL689916 | 0.83 | ALDH1A1 (0.44) | KDM4EALDH1A1MAPK14MAPK10GSK3A | |
| SCHEMBL16106403 | 0.83 | GSK3A (0.43) | KDM4EALDH1A1MAPK14MAPK10GSK3A | |
| SCHEMBL692574 | 0.83 | GSK3A (0.41) | KDM4EALDH1A1MAPK14MAPK10GSK3A | |
| SCHEMBL692947 | 0.80 | HTT (0.42) | KDM4EALDH1A1MAPK14GSK3ASMN1; SMN2 | |
| SCHEMBL721145 | 0.79 | LMNA (0.44) | KDM4EALDH1A1MAPK14GSK3A | |
| SCHEMBL690241 | 0.78 | MAPK14 (0.41) | ALDH1A1MAPK14 | |
| SCHEMBL690623 | 0.78 | RARG (0.41) | KDM4EALDH1A1TSHRMAPK10PARP1 | |
| SCHEMBL690666 | 0.76 | GSK3A (0.37) | KDM4EALDH1A1MAPK14MAPK10GSK3A | |
| SCHEMBL690060 | 0.75 | MAPK14 (0.53) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |