Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 13/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 11/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | PRKACA | P17612 | 2/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852412 | 0.88 | TMEM97 (0.61) | TMEM97SIGMAR1HTR1ASLC6A4OPRM1 | |
| SCHEMBL1849516 | 0.82 | SIGMAR1 (0.73) | TMEM97SIGMAR1HTR1ASLC6A4OPRM1 | |
| SCHEMBL13502652 | 0.81 | SIGMAR1 (0.68) | TMEM97SIGMAR1HTR1ASLC6A4DRD2 | |
| SCHEMBL1855275 | 0.81 | CHEK1 (0.63) | TMEM97SIGMAR1HTR1ASLC6A4ADRA1D | |
| SCHEMBL31279383 | 0.77 | TMEM97 (0.51) | TMEM97SIGMAR1HTR1ASLC6A4OPRM1 | |
| SCHEMBL13064304 | 0.75 | TMEM97 (0.59) | TMEM97SIGMAR1HTR1ASLC6A4DRD2 | |
| SCHEMBL2064431 | 0.75 | SLC6A4 (0.64) | TMEM97SIGMAR1HTR1ASLC6A4ADRA1D | |
| SCHEMBL31279305 | 0.74 | TMEM97 (0.49) | TMEM97SIGMAR1HTR1ASLC6A4OPRM1 | |
| SCHEMBL1853604 | 0.73 | SIGMAR1 (0.69) | TMEM97SIGMAR1HTR1ASLC6A4DRD2 | |
| SCHEMBL31338246 | 0.73 | TMEM97 (0.51) | TMEM97SIGMAR1HTR1ASLC6A4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323659-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | Abbott Laboratories (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010017150-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | WO | disclosed |