Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 3/20 | 0.42 |
| ▸ | CES1 | P23141 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18503221 | 1.00 | TDP1 (0.53) | TDP1L3MBTL1SIGMAR1MEN1KMT2A | |
| SCHEMBL18503215 | 1.00 | TDP1 (0.53) | TDP1L3MBTL1SIGMAR1MEN1KMT2A | |
| SCHEMBL18503223 | 1.00 | TDP1 (0.53) | TDP1L3MBTL1SIGMAR1MEN1KMT2A | |
| SCHEMBL18503188 | 1.00 | TDP1 (0.53) | TDP1L3MBTL1SIGMAR1MEN1KMT2A | |
| SCHEMBL18503164 | 0.93 | TDP1 (0.53) | TDP1L3MBTL1SIGMAR1MEN1KMT2A | |
| SCHEMBL18503166 | 0.93 | TDP1 (0.53) | TDP1L3MBTL1SIGMAR1MEN1KMT2A | |
| SCHEMBL18503168 | 0.93 | TDP1 (0.53) | TDP1L3MBTL1SIGMAR1MEN1KMT2A | |
| SCHEMBL18503261 | 0.93 | TDP1 (0.53) | TDP1L3MBTL1SIGMAR1MEN1KMT2A | |
| SCHEMBL18503253 | 0.93 | TDP1 (0.53) | TDP1L3MBTL1SIGMAR1MEN1KMT2A | |
| SCHEMBL28671150 | 0.91 | L3MBTL1 (0.50) | TDP1L3MBTL1MEN1KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207299-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES FOR TREATING OR PREVENTING A SARS-COV-2 INFECTION | CHIMERIX, INC. (US) | 2024-06-27 | — | — | US | disclosed |
| US-20240207299-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES FOR TREATING OR PREVENTING A SARS-COV-2 INFECTION | CHIMERIX, INC. (US) | 2024-06-27 | — | — | US | disclosed |
| US-20220002335-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2022-01-06 | — | — | US | disclosed |
| US-10941175-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | CHIMERIX, INC. (US) | 2021-03-09 | — | — | US | disclosed |
| US-20200199167-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2020-06-25 | — | — | US | disclosed |
| US-10407457-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | CHIMERIX, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| US-20170253628-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2017-09-07 | — | — | US | disclosed |
| US-20170253628-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2017-09-07 | — | — | US | disclosed |
| US-9708359-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | CHIMERIX, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-9708359-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | CHIMERIX, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-9701706-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | CHIMERIX, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-9701706-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | CHIMERIX, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-20170137454-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2017-05-18 | — | — | US | disclosed |
| US-20170137454-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2017-05-18 | — | — | US | disclosed |
| US-20170044202-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2017-02-16 | — | — | US | disclosed |
| US-20170044202-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10407457-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | TYMP, PNP, DPYD | TDP1 208/4885L3MBTL1 3636/4885SIGMAR1 4485/4885 |
| US-20200199167-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | TYMP, PNP, DPYD | TDP1 208/4885L3MBTL1 3636/4885SIGMAR1 4485/4885 |
| US-20220002335-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | TYMP, PNP, DPYD | TDP1 208/4885L3MBTL1 3636/4885SIGMAR1 4485/4885 |
| US-20170137454-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | TYMP, PNP, DPYD | TDP1 208/4885L3MBTL1 3636/4885SIGMAR1 4485/4885 |
| US-20170253628-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | TYMP, PNP, DPYD | TDP1 208/4885L3MBTL1 3636/4885SIGMAR1 4485/4885 |
| US-20170044202-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF | TYMP, ITPA, IMPDH1 | TDP1 302/4885L3MBTL1 3382/4885SIGMAR1 4324/4885 |
| US-20240207299-A1 | PYRROLOPYRIMIDINE NUCLEOSIDES FOR TREATING OR PREVENTING A SARS-COV-2 INFECTION | PNP, ACE2, TYMP | TDP1 272/4885L3MBTL1 3798/4885SIGMAR1 4720/4885 |
| US-10941175-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | TYMP, PNP, DPYD | TDP1 208/4885L3MBTL1 3636/4885SIGMAR1 4485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.