Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 5/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1846922 | 0.93 | MEN1 (0.40) | MEN1KMT2AEP300TACR1 | |
| SCHEMBL1846958 | 0.87 | MEN1 (0.36) | MEN1KMT2AEP300 | |
| SCHEMBL1846837 | 0.87 | PRKAB2 (0.37) | EP300CDK9CHRM2CHRM1CHRM3 | |
| SCHEMBL1849014 | 0.87 | MEN1 (0.35) | MEN1KMT2AEP300 | |
| SCHEMBL1847077 | 0.84 | EP300 (0.36) | EP300TACR1 | |
| SCHEMBL1847309 | 0.84 | EP300 (0.36) | EP300CDK9CHRM2CHRM1CHRM3 | |
| SCHEMBL1848429 | 0.83 | MEN1 (0.51) | MEN1KMT2A | |
| SCHEMBL1850456 | 0.82 | MEN1 (0.38) | MEN1KMT2ATACR1 | |
| SCHEMBL2158549 | 0.81 | MEN1 (0.44) | MEN1KMT2AEP300 | |
| SCHEMBL1848054 | 0.80 | PRKAB2 (0.38) | EP300TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324015-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-aventis (FR) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010012964-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-02-04 | — | — | WO | disclosed |