Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 11/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18502976 | 0.78 | NOTUM (0.38) | HPGDNOTUMKDM4EKMT2AL3MBTL1 | |
| SCHEMBL18508604 | 0.78 | NOTUM (0.38) | HPGDNOTUMKDM4EKMT2AL3MBTL1 | |
| SCHEMBL3089434 | 0.68 | NOTUM (0.38) | HPGDNOTUM | |
| SCHEMBL3089437 | 0.68 | NOTUM (0.38) | HPGDNOTUM | |
| SCHEMBL23064327 | 0.66 | MAPT (0.45) | HPGDSMN1; SMN2KDM4EKMT2AMAPT | |
| SCHEMBL4373753 | 0.66 | PDE2A (0.45) | HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL13707569 | 0.66 | PDE2A (0.45) | HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL23064328 | 0.66 | MAPT (0.45) | HPGDSMN1; SMN2KDM4EKMT2AMAPT | |
| SCHEMBL4373756 | 0.66 | PDE2A (0.45) | HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL29057163 | 0.65 | NOTUM (0.35) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027600-A1 | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS | FORUM PHARMACEUTICALS, INC. (US) | 2017-02-16 | — | — | WO | disclosed |