Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13707569 | 1.00 | PDE2A (0.45) | PDE2AMAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL4373753 | 1.00 | PDE2A (0.45) | PDE2AMAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL23064328 | 0.86 | MAPT (0.45) | PDE2AMAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL23064327 | 0.86 | MAPT (0.45) | PDE2AMAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL31251637 | 0.82 | MAPT (0.62) | MAPTSMN1; SMN2KDM4ELMNAHPGD | |
| SCHEMBL541829 | 0.80 | CES2 (0.46) | MAPTSMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL4880854 | 0.80 | CES2 (0.46) | MAPTSMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL13548653 | 0.80 | PDE2A (0.42) | PDE2AMAPTSMN1; SMN2KDM4EGRIN2D | |
| SCHEMBL29254639 | 0.77 | PDE2A (0.46) | PDE2AMAPTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11408258 | 0.77 | PTGS2 (0.46) | PDE2AMAPTSMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |