Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 18/20 | 0.89 |
| ▸ | MET | P08581 | 10/20 | 0.89 |
| ▸ | MERTK | Q12866 | 4/20 | 0.89 |
| ▸ | PLK4 | O00444 | 1/20 | 0.89 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.89 |
| ▸ | RET | P07949 | 1/20 | 0.89 |
| ▸ | KDR | P35968 | 1/20 | 0.89 |
| ▸ | FLT3 | P36888 | 1/20 | 0.89 |
| ▸ | MST1R | Q04912 | 1/20 | 0.89 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.89 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.89 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.89 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.89 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.89 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Merestinib SCHEMBL679002 | 0.94 | AXL (1.00) | AXLMETMERTKPLK4NTRK1 | |
| Merestinib SCHEMBL29493094 | 0.94 | AXL (1.00) | AXLMETMERTKPLK4NTRK1 | |
| SCHEMBL18165614 | 0.94 | AXL (0.80) | AXLMETMERTKPLK4NTRK1 | |
| Merestinib SCHEMBL29726013 | 0.94 | AXL (0.99) | AXLMETMERTKPLK4NTRK1 | |
| Merestinib SCHEMBL680728 | 0.94 | AXL (0.99) | AXLMETMERTKPLK4NTRK1 | |
| SCHEMBL12190616 | 0.92 | AXL (0.85) | AXLMETMERTKPLK4NTRK1 | |
| SCHEMBL22996143 | 0.90 | AXL (0.92) | AXLMETMERTKPLK4NTRK1 | |
| SCHEMBL680542 | 0.90 | AXL (0.81) | AXLMETMERTKPLK4NTRK1 | |
| SCHEMBL679128 | 0.89 | MET (0.91) | AXLMETMERTKPLK4NTRK1 | |
| SCHEMBL23629471 | 0.88 | AXL (0.88) | AXLMETMERTKPLK4NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027544-A1 | COMBINATION THERAPY FOR CANCER | IMCLONE LLC (US) | 2017-02-16 | — | — | WO | disclosed |