Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158729 | 0.93 | MEN1 (0.46) | MEN1KMT2AKDM4COXTRFFAR4 | |
| SCHEMBL1848429 | 0.89 | MEN1 (0.51) | MEN1KMT2APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL1846923 | 0.84 | MEN1 (0.40) | MEN1KMT2ARORCBACE1ALDH1A1 | |
| SCHEMBL1846922 | 0.83 | MEN1 (0.40) | MEN1KMT2APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL2158549 | 0.82 | MEN1 (0.44) | MEN1KMT2APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL476406 | 0.80 | MEN1 (0.44) | MEN1KMT2AKDM4COXTRRORC | |
| SCHEMBL1850456 | 0.77 | MEN1 (0.38) | MEN1KMT2A | |
| SCHEMBL1850453 | 0.76 | MEN1 (0.38) | MEN1KMT2A | |
| SCHEMBL2682498 | 0.74 | KMT2A (0.38) | MEN1KMT2AKDM4COXTRCHRNB2 | |
| SCHEMBL9335079 | 0.73 | MEN1 (0.95) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324015-B1 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2013-07-03 | — | — | EP | disclosed |
| EP-2324015-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-aventis (FR) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010012964-A2 | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-02-04 | — | — | WO | disclosed |