Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1848647 | 0.91 | ADORA3 (0.54) | RAB9ANPC1ADORA3ACHEADORA2A | |
| SCHEMBL1848588 | 0.89 | ADORA3 (0.58) | RAB9ANPC1ADORA3SMN1; SMN2ACHE | |
| SCHEMBL1846481 | 0.89 | ADORA2A (0.48) | RAB9ANPC1ADORA3SMN1; SMN2ACHE | |
| SCHEMBL1850214 | 0.88 | ADORA3 (0.49) | RAB9ANPC1ADORA3ACHEADORA2A | |
| SCHEMBL1850215 | 0.88 | ADORA3 (0.49) | RAB9ANPC1ADORA3ACHEADORA2A | |
| SCHEMBL1849219 | 0.88 | ADORA3 (0.49) | RAB9ANPC1ADORA3ACHEADORA2A | |
| SCHEMBL1847530 | 0.88 | ADORA3 (0.59) | RAB9ANPC1ADORA3ACHEADORA2A | |
| SCHEMBL1849827 | 0.87 | ADORA2A (0.49) | ADORA3ACHEADORA2AKDM4EADORA1 | |
| SCHEMBL1849984 | 0.86 | GSK3B (0.45) | RAB9ANPC1ADORA3SMN1; SMN2ACHE | |
| SCHEMBL1847935 | 0.84 | ADORA2A (0.62) | RAB9ANPC1ADORA3SMN1; SMN2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197860-B1 | NEW COMPOUNDS AS ADENOSINE A1 RECEPTOR ANTAGONISTS | PALOBIOFARMA SL (ES) | 2011-05-25 | — | — | EP | claimed |
| US-8410282-B2 | Compounds as adenosine A1 receptor antagonists | PALOBIOFARMA, S.L. (ES) | 2013-04-02 | — | — | US | disclosed |