Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10415949 | 0.86 | KMT2A (0.75) | MEN1KMT2AMAPTL3MBTL1RAB9A | |
| SCHEMBL27881516 | 0.85 | MEN1 (0.74) | MEN1KMT2AMAPTL3MBTL1RAB9A | |
| SCHEMBL18508426 | 0.85 | MEN1 (0.74) | MEN1KMT2AMAPTL3MBTL1RAB9A | |
| SCHEMBL6849222 | 0.84 | MEN1 (0.71) | MEN1KMT2AMAPTL3MBTL1RAB9A | |
| SCHEMBL27881514 | 0.81 | KMT2A (0.68) | MEN1KMT2AMAPTL3MBTL1RAB9A | |
| SCHEMBL8435844 | 0.79 | GAA (0.73) | MEN1KMT2AMAPTL3MBTL1RAB9A | |
| SCHEMBL21081341 | 0.78 | MEN1 (0.64) | MEN1KMT2AMAPTL3MBTL1RAB9A | |
| SCHEMBL5797619 | 0.78 | MEN1 (0.77) | MEN1KMT2AMAPTL3MBTL1RAB9A | |
| SCHEMBL795882 | 0.77 | MEN1 (0.62) | MEN1KMT2AMAPTL3MBTL1RAB9A | |
| SCHEMBL927388 | 0.77 | MEN1 (0.62) | MEN1KMT2AMAPTL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027359-A1 | PYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2017-02-16 | — | — | WO | disclosed |
| CN-102807574-A | Novel pyrido sulfur nitrogen 7-membered ring derivatives adopted as anti-tumor drugs, preparation method and applications thereof | CHANGCHUN DISCOVERY SCIENCES LTD | 2012-12-05 | — | — | CN | disclosed |