Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 11/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | EED | O75530 | 2/20 | 0.47 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.45 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18490166 | 0.89 | GABRG2 (0.49) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL18490144 | 0.89 | GABRG2 (0.49) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL18490143 | 0.80 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL18490304 | 0.76 | SMN1; SMN2 (0.69) | MEN1KMT2AMAPK1HSD17B10LMNA | |
| SCHEMBL18501504 | 0.75 | GABRG2 (0.47) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL18501503 | 0.75 | GABRG2 (0.47) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL18490071 | 0.75 | SLC5A1 (0.53) | GABRA2SLC5A1SLC5A2GABRB2ALDH1A1 | |
| SCHEMBL20286343 | 0.75 | GABRG2 (0.44) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL20289431 | 0.74 | GAA (0.47) | GABRG2GABRB3GABRA5GABRA2GABRA1 | |
| SCHEMBL14692520 | 0.73 | PDE4B (0.46) | GABRG2GABRB3GABRA5GABRA2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027312-A1 | GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2017-02-16 | — | — | WO | disclosed |
| WO-2017027310-A1 | GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2017-02-16 | — | — | WO | disclosed |
| WO-2017027309-A1 | GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2017-02-16 | — | — | WO | disclosed |