Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Trifluoromethanesulfonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 5/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoromethanesulfonic Acid SCHEMBL2285727 | 0.90 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1EPHX1CA1CA2 | |
| SCHEMBL27493794 | 0.90 | TSHR (0.40) | ALDH1A1L3MBTL1EPHX1CA1CA2 | |
| Trifluoromethanesulfonic Acid SCHEMBL3361058 | 0.88 | EPHX1 (0.43) | ALDH1A1L3MBTL1EPHX1CA1CA2 | |
| Trifluoromethanesulfonic Acid SCHEMBL27669034 | 0.88 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1EPHX1CA1CA2 | |
| Trifluoromethanesulfonic Acid SCHEMBL27910342 | 0.88 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1EPHX1CA1CA2 | |
| Trifluoromethanesulfonic Acid SCHEMBL12506224 | 0.85 | CA1 (0.40) | ALDH1A1L3MBTL1EPHX1CA1CA2 | |
| Trifluoromethanesulfonic Acid SCHEMBL2958868 | 0.85 | EPHX1 (0.41) | ALDH1A1L3MBTL1EPHX1CA1CA2 | |
| Trifluoromethanesulfonic Acid SCHEMBL29171770 | 0.85 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1EPHX1CA1CA2 | |
| Trifluoromethanesulfonic Acid SCHEMBL15667317 | 0.85 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1EPHX1CA1CA2 | |
| Trifluoromethanesulfonic Acid SCHEMBL28112194 | 0.85 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1EPHX1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1433785-A1 | Agents for the coloration of keratinous fibres | Henkel Kommanditgesellschaft auf Aktien (DE) | 2004-06-30 | — | — | EP | claimed |
| EP-3172214-B1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2020-05-13 | — | — | EP | disclosed |
| EP-3169671-B1 | 1-(5-(TERT.-BUTYL)ISOXAZOL-3-YL)-3-(4-((PHENYL)ETHYNYL)PHENYL)UREA DERIVATIVES AND RELATED COMPOUNDS AS FLT3 INHIBITORS FOR TREATING CANCER | SUNSHINE LAKE PHARMA CO LTD (CN) | 2019-08-21 | — | — | EP | disclosed |
| EP-2324009-A1 | PROCESS FOR PREPARING CERTAIN CINNAMIDE COMPOUNDS | Eisai R&D Management Co., Ltd. (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010025197-A1 | PROCESS FOR PREPARING CERTAIN CINNAMIDE COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-04 | — | — | WO | disclosed |
| EP-1433785-A1 | Agents for the coloration of keratinous fibres | Henkel Kommanditgesellschaft auf Aktien (DE) | 2004-06-30 | — | — | EP | disclosed |