Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.33 |
| ▸ | TYMS | P04818 | 3/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12956542 | 0.79 | CA9 (0.42) | CA9CYP11B1CYP11B2CYP19A1NPC1 | |
| SCHEMBL14779528 | 0.79 | CYP11B1 (0.50) | CA9CYP11B1CYP11B2CYP19A1NPC1 | |
| SCHEMBL18513259 | 0.79 | CYP11B1 (0.43) | CA9CYP11B1CYP11B2CYP19A1NPC1 | |
| SCHEMBL13726349 | 0.79 | KIF11 (0.46) | CA9CYP11B1CYP11B2CYP19A1NPC1 | |
| SCHEMBL18513252 | 0.79 | CYP11B1 (0.40) | CA9CYP11B1CYP11B2CYP19A1NPC1 | |
| SCHEMBL22428842 | 0.75 | CA9 (0.39) | CA9CYP11B1CYP11B2CYP19A1NPC1 | |
| SCHEMBL18497036 | 0.75 | CYP11B1 (0.40) | CYP11B1CYP11B2CYP19A1MAOAMAOB | |
| SCHEMBL1119381 | 0.73 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP19A1CYP1A2TYMS | |
| SCHEMBL27136344 | 0.71 | CA9 (0.42) | CA9CYP11B1CYP11B2CYP19A1NPC1 | |
| SCHEMBL27140279 | 0.71 | CA9 (0.42) | CA9CYP11B1CYP11B2CYP19A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3334717-B1 | ARYL-SUBSTITUTED DIHYDROQUINOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | NEOMED INST (CA) | 2020-07-01 | — | — | EP | disclosed |
| WO-2017024408-A1 | ARYL-SUBSTITUTED DIHYDROQUINOLINONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | NEOMED INSTITUTE (CA) | 2017-02-16 | — | — | WO | disclosed |