SCHEMBL18516293

SCHEMBL18516293

O=CCC(=O)Nc1ccc(Oc2ccnc3cc(C(=O)N4CCCC4)sc23)c(F)c1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MET P08581 20/20 0.79
KDR P35968 19/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL307536 0.88 MET (1.00) METKDR
SCHEMBL308435 0.84 MET (0.81) METKDR
SCHEMBL12285925 0.83 MET (0.71) METKDR
SCHEMBL12252284 0.83 MET (0.70) METKDR
Hydrochloric Acid SCHEMBL3562772 0.82 MET (0.76) METKDR
Hydrochloric Acid SCHEMBL3567378 0.82 MET (0.85) METKDR
Hydrochloric Acid SCHEMBL3577248 0.82 MET (0.75) METKDR
SCHEMBL12252283 0.82 MET (0.69) METKDR
SCHEMBL3559626 0.81 MET (1.00) METKDR
SCHEMBL3559613 0.81 MET (0.83) METKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1957498-B1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING METHYLGENE INC (CA) 2017-02-15 EP disclosed